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NMN works right away to increase performance and doesn't need to be loaded like creatine or beta alanine.
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NMN is converted into NAD+ which is an important molecule that promotes the process of glycolysis and the kreb's cycle, this means it increases the rate of energy production from our body's reserve of fats and glucose.
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This well designed study demonstrates that NMN can boost aerobic capacity performance metrics by up to 30% in trained athletes, this beats beta alanine by a long shot.
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NMN is also known for its anti-aging benefits. NAD+ levels decline rapidly with age, NAD+ levels can be reduced by up to 50% past the age of 30. NMN supplementation potently boosts NAD+ production and can increase insulin sensitivity, reverse mitochondrial dysfunction, and extend the lifespan in aging populations.
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Nicotinamide Mononucleotide(NMN)
NMN is a naturally occurring nucleotide with great potential, it has been shown to improve aerobic exercise capacity,
MAIN HUMAN NMN STUDY:
https://jissn.biomedcentral.com/articles/10.1186/s12970-021-00442-4
https://youtu.be/gi3vWDovF0Y - Video explaining this exact study and interpreting the results
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7238909/
ElevATP
ElevATP is a patented ingredient supported by several human trials in increasing performance and ATP production significantly.
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A randomized control trial demonstrated that a small dose of elevATP was able to increase systemic ATP by 20-70% 30-90min of supplementation in humans.
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The benefits of elevATP can be seen right after supplementation and does not require a 'loading phase'.
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elevATP can support increased work capacity and power output, which is especially useful in improving cardiovascular fitness.
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elevATP is FDA approved and is not banned in any sporting organizations.
B, Argumedo R, Shu C, Huynh L, Pietrzkowski Z. Effect of the dietary supplement ElevATP on blood ATP level: An acute pilot clinical study. J Aging Res Clin Practice. 2013;2:178–84.
Reyes-Izquierdo T, Shu C, Argumedo R, Nemzer B, Pietrzkowski Z. The effect of elevATPTM on whole blood ATP levels: a single dose, crossover clinical study. J Aging Res Clin Practice. 2014;3:56–60.
Joy, J. M., Falcone, P. H., Vogel, R. M., Mosman, M. M., Kim, M. P., & Moon, J. R. (2015). Supplementation with a proprietary blend of ancient peat and apple extract may improve body composition without affecting hematology in resistance-trained men. Applied Physiology, Nutrition, and Metabolism, 40(11), 1171–1177. https://doi.org/10.1139/apnm-2015-0241
Joy, J. M., Vogel, R. M., Moon, J. R., Falcone, P. H., Mosman, M. M., & Kim, M. P. (2016). Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men. Journal of the International Society of Sports Nutrition, 13(1). doi:10.1186/s12970-016-0136-9
https://pubmed.ncbi.nlm.nih.gov/26489051
Sodium Nitrate
Sodium Nitrate is popular within the cyclist community and has been shown to be a positive ergogenic aid in aerobic and anaerobic exercise in humans. Supplementing with nitrates is an
effective way to increase nitric oxide production which leads to increased blood flow to the working tissues. Increasing tissue perfusion (blood flow) during exercise can help reduce the aerobic cost of exercise, leading to improved cardiovascular function
and better endurance during exercise. Here are some interesting trials which support the benefits of nitrates in endurance sports:
Nitrate supplementation's improvement of 10-km time-trial performance
in trained cyclists - https://pubmed.ncbi.nlm.nih.gov/22248502/
Whole beetroot consumption acutely improves running performance-
https://pubmed.ncbi.nlm.nih.gov/22709704/
Dietary nitrate supplementation improves team sport-specific intense
intermittent exercise performance -
https://pubmed.ncbi.nlm.nih.gov/23370859/
125mcg 5-Methylfolate (Vitamin B9) + 500mcg Methylcobalamin (Vitamin B12)
High doses of NMN (1000mg+) can cause increased homocysteine levels and decrease methyl donors in the body, which can lead to brain fog, cellular impairment in DNA replication and maintaining homeostasis in our organ systems.
5-methylfolate and methylcobalamin are both effective methyl donors which have been shown to replace the losses associated with NMN supplementation and attenuate the negative side effects of high dose/chronic use of all NAD+ precursors (including NMN).
